Welcome to JAAN's science class!!

Big hi to all of you! I'm an undergraduate following a Bsc in bioscience. Trust me I know the feeling of surfing around the net for ages and getting nothing in return! Or getting something worthless for the time we spent surfing. So I started this blog adding the science stuff I have noted which I think might help someone in their home work. Ok then enjoy!

06 May 2012

Serotonin the neurotransmitter


Serotonin i.e. 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter that is said to be helping to relay signals from one area of the brain to another. However its primary functions are found in gastrointestinal tract as 90% of total serotonin is located in the enterochromaffin cells in the gut. 

Serotonin is made via a unique biochemical conversion process that begins with Tryptophan. Tryptophan is a building block to proteins. In the synthesis of serotonin, Tryptophan hydroxylase the enzyme combines with tryptophan to form 5-hydroxytryptophan metabolite that later converts to Serotonin.

 On top a L-tryptophan molecule with an arrow down to a 5-HTP molecule.  Tryptophan hydroxylase catalyses this reaction with help of O2 and tetrahydrobiopterin which becomes water and dihydrobiopterin. From the 5-HTP molecule goes an arrow down to a serotonin molecule. Aromatic L-amino acid decarboxylase or 5-Hydroxytryptophan decarboxylase catalyses this reaction with help of pyridoxal phosphate. From the serotonin molecule goes an arrow to a 5-HIAA molecule at the bottom ot the image. Monoamine oxidase catalyses this reaction, in the process O2 and water is consumed, and ammonia and hydrogen peroxide is produced.
Via wikipedia.org

As mentioned earlier serotonin helps to distribute messages across the brain. Brain cells related to mood, appetite, sleep, memory, learning, temperature regulation, sexual desire and some social behaviour are influenced either directly or indirectly by serotonin due to the widespread distribution in the brain. 
It can also affect the functioning of the cardiovascular system, muscles, and various elements in the endocrine system.

When it comes to mental health, it is widely believed that a serotonin deficiency plays a role in depression but there is no way to measure its levels in the living brain. Therefore, there have not been any studies proving that brain levels of this or any neurotransmitter are in short supply when depression or any mental illness develops. People who suffer from depression shows lower serotonin levels in blood levels but still it is not revealed that whether the blood levels reflect the brain's level of serotonin.

Antidepressant medications such as SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin and norepinephrine reuptake inhibitors) that work on serotonin levels are believed to lower the symptoms of depression, but their exact function is not fully understood.

Recent studies show that when the Mycobacterium vaccae, which occurs naturally in soil and is often breathed in when spending much time nature, is injected into mice, it stimulates neuron growth and causes serotonin levels in blood to increase. So that the bacteria could have antidepressant benefits but it is not yet revealed whether it has an effect on human.


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